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Appomattox Drug Store

"When You Absolutely, Positively, Want To Feel Better"

About Us

Appomattox Drug Store has been a cornerstone of the community in Appomattox, VA, and the surrounding areas since 1969. As a locally- and family-owned establishment, we take pride in offering personalized service and a warm atmosphere to all our customers. Specializing in pharmacy services, prescription refills, and home health products, we cater to your healthcare needs with care and dedication. Our wide selection of natural medicines provides alternative remedies for a holistic approach to wellness. We also offer compliance packaging and bubble packaging to ensure safe and convenient medication management. Visit Appomattox Drug Store for all your health needs and experience the difference that comes with quality service from a trusted local pharmacy.

Areas Served

What We Offer

Our Specialties include:

Locally-Owned
Family-Owned

Our Services include:

Medication Refills
Prescription Refills
General Store
Health Wellness
Natural Remedies
Pharmacy
Personal Care
Quality Care
Compliance Packaging
Drive-Thru Service
Diabetic Shop
Drug Store

Our Products include:

Medication
Health Equipment
Allergy Medication
Willow Tree Angels
Dollar Reader Reading Glasses
Allerga
Claritin
Robitussin
Nebulizers
Oral Care
Eye Care
Hygiene
Diabetes Supplies
Natural Medication
Natural Medicine
Medicine
Walkers
Diabetic Shoes
Dollar Items
Birthday Cards
Bubble Packs
Cough Medicine

Testimonials

On 2/10/2026 Patricia Coy had this to say:
Love them!! They know my family by name and face!!! They are the sweetest!

On 2/4/2026 Carrie H had this to say:
Sherry with the medical supplies saved me! Due to a delay in shipment I was in a desperate way. I called and she was extremely pleasant and helpful and hooked me up with much needed supplies to tide me over! Couldn't have asked for a nicer person!

On 10/29/2025 Amanda had this to say:
Nice! Kind friendly, convenient family-owned

On 8/15/2025 Laura Coleman had this to say:
Nice little store. Very friendly. Does have a drive through window.

On 4/23/2025 Robert Spangler had this to say:
Old time service. Super friendly staff.

Contact Us

Appomattox Drug Store
2046 Confederate Blvd Appomattox, VA 24522
Phone: (434) 352-7161
Email: office@appomattoxdrug.com

Across the street from McDonald's

Where To Find Us

Payment Types Accepted

American Express, Android Pay, Apple Pay, Personal Checks, Debit Cards, Discover, MasterCard, Visa

Our Hours

Holiday Hours May Vary. Please Call For Details.

Monday: 8:30 AM - 6:00 PM
Tuesday: 8:30 AM - 6:00 PM
Wednesday: 8:30 AM - 6:00 PM
Thursday: 8:30 AM - 6:00 PM
Friday: 8:30 AM - 6:00 PM
Saturday: 8:30 AM - 2:00 PM

News

Our figurative ornaments are more than decorations—they’re expressions of friendship, love, hope, and inspiration. Perfect for holidays, birthdays, teacher gifts, baby showers, anniversaries, or just because! ✨ Limited-Time Special: $15.00 each! Stop by Appomattox Drug Store and find the perfect ornament to brighten someone’s day.

Prevagen is backed by published studies confirming its safety. Its key ingredient, apoaequorin (say it like a-po-ah-kwor-in), was first discovered in jellyfish and is now scientifically produced just for Prevagen. ✨ It’s a one-of-a-kind formula—only found in Prevagen! Stop by Appomattox Drug Store to learn more or pick up your bottle today!

Say goodbye to medication confusion and hello to convenience with our compliance packaging and bubble packages! Our Appomattox Drug Store is here to make managing your medications a breeze. Ask us about these options today!